Nutritional Value of Guyabano
Guyabano fruit is high in carbohydrates, particularly fructose. The fruit also contains significant amounts of vitamin C, vitamin B1, and vitamin B2.

Uses of concoction prepared from pulverized guyabano seeds
As skin astringent
Treat muscle spasms
Treat dysentery
To purge parasites such as bedbugs and headlice
Uses of concoction prepared from guyabano leaves
As sudorific or to cause one to sweat
As an agent to cause vomiting (emetic)
As tranquilizer and sedative
To treat head lice and bedbugs and other parasites
To treat inflammation
Treatment for eczema and skin diseases
Treatment of catarrh or inflammation of mucous membrane in the respiratory tract.
Treatment of pain and inflammation associated with arthritis, rheumatism
Uses of guyabano fruit / Juice from guyabano fruit
Used as diuretic,
Treatment of hematuria and urethritis
Treat Dysentery
Treat Scurvy
Uses of concoction of bark, roots and leaves
To treat diabetes
As tranquilizer and sedative

Guyabano Cautions And Side Effects
Concoctions of leaves, seeds and barks are not recommended for internal consumption to young children, pregnant and lactating women

Guyabano bark has been reported to contain alkaloids called anonaine and anoniine that is high in hydrocyanic acid. Small traces of hydrocyanic acid may also be found in leaves. Hydrocyanic acid is a colorless substance that is considered poisonous.

In studies done from a Caribbean laboratory, Guyabano contains annonacin that is suggested to have a connection in the development of atypical Parkinson’s disease. Guyabano is not recommended for people who have motor control ldifficulty or suspected of having Parkinson's disease.

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Analyses of the fruit flesh showed that it is deficient in calcium and phosphorus. According to Jansen and Donath it is deficient in vitamin A. Hermano and Sepulveda, however, report that it is an excellent source of vitamins B and C. Prinsan-Geerlings reports that the flesh of the fruit contains saccharose 2.53%, dextrose 5.05% and levulose 0.04 %.

The bark was studied by Greshoff who isolated the amorphous alkaloid, soluble in sodium or potassium hydroxide, but according to Ridley and Daruty is astringent, and is used in powdered form for diarrhea and dysentery. Kirtikar, Basu and Nadkarni say that it is much used as tonic by the Malays and Chinese. The fruit is used as an anthelmintic. The unripe and dried fruit as astringent. Used to cure diarrhea among the Amerindians. With sugar, the pulp is refreshing, and is prescribed for diarrhea in Guiana, Antilles and Reunion. Tavera reports the roots are used by Amerindians to treat epilepsy.

I am not done yet. There are more!

1. The fruit is claimed to be a miraculous natural cancer cell killer 10,000 times stronger than chemotherapy. It has anti tumor effect and a proven remedy to all types of cancer.

2. A potent antimicrobial agent for both bacterial and fungal infections. Effective against internal parasites and worms, lowers high blood pressure and is used for depression, stress and nervous disorders.

3. It protects immune system and helps avoid deadly infections.


Guyabano and Diabetes

An article in “African Journal of Traditional Complementary and Alternative Medicine” about in 2008 have reported that a clinical study done on rats induced with diabetes mellitus then fed with guyabano (Annona Muricata Linn) extracts showed positive effects of lowering the blood sugar levels in animals. Another study reported by the same publication showed that animals with induced diabetes mellitus that consumed guyabano extract has shoed remarkable increase of antioxidants in their blood and that there is less liver damage. The findings of this laboratory animal study suggest that (guyabano) Annona muricata extract has a protective, beneficial effect on hepatic tissues subjected to STZ-induced oxidative stress, possibly by decreasing lipid peroxidation and indirectly enhancing production of insulin and endogenous antioxidants. Although the reports suggested that guyabano extracts have promising medicinal benefits for diabetes mellitus. there is no sufficient study done on its effects to humans with diabetes.
www.ncbi.nlm.nih.gov/pubmed/20162039

Guyabano and Inflammation

In a report that was published in “International Journal of Molecular Sciences” dated 2010, Antinociceptive and anti-inflammatory activities of the ethanol extract from guyabano leaves (Annona muricata Linn) were investigated in animal models.. In a chemically induced edema to the paw of rats showed that the guyabano ethanol extract has significantly reduced the exudate volume. These results suggest that Annona muricata can be an active source of substances with antinociceptive and anti-inflammatory activities.
www.ncbi.nlm.nih.gov/pubmed/20559502

Guyabano and Cancer

In a study published in the “ Journal of Medicinal Chemistry”, fourteen structurally diverse Annonaceous acetogenins, found in Guyabano extract were identified and tested for their ability to inhibit the growth of adriamycin resistant human mammary adenocarcinoma cells. This cell line is known to be multidrug resistant cancer cells. Some of the acetogenins from the guyabano extract were found to be more potent than adriamycin and thus may have chemotherapeutic potential, especially with regard to multidrug resistant tumors..
www.ncbi.nlm.nih.gov/pubmed/9207950?dopt=Citation

Guyabano and Herpes Simplex Virus

A study published in “Journal of Ethnopharmacology”, 1mg/ml of ethanol extract of Annona muricata (Annonaceae, Guyabano) in Petunia nyctaginiflora (Solanaceae) aqueous extract can inhibit the activity of Herpes simplex virus-1 (HSV-1).
www.ncbi.nlm.nih.gov/pubmed/9687085?dopt=Citation

Guyabano and Depression
In a study published in the “Journal of Pharmacy and Pharmacology”, extracts from the fruit and the leaves of Guyabano (Annona muricata - Annonaceae) contains three alkaloids, annonaine (1), nornuciferine (2) and asimilobine (3), that upon tests have shown to inhibit binding of [3H]rauwolscine to 5-HTergic 5-HT1A receptors in calf hippocampus. These results imply that Guyabano fruit (Annona muricata) possesses anti-depressive effects.
www.ncbi.nlm.nih.gov/pubmed/9401954#

Guyabano and Antibacterial Effects

In a report published in “Revista do Instituto de Medicina Tropical de São Paulo”, a study has been made to determine the antibacterial effects of aqueous and ethanolic extracts of seeds of moringa (Moringa oleifera) and pods of guyabano (Annona muricata). The aqueous extracts of guyabano (annona muricata) showed an antibacterial effect against Staph aureus and Vibrio cholerae, but the antibacterial activity by the ethanol extracts of this plant was not demonstrated.
www.ncbi.nlm.nih.gov/pubmed/20602021